产品名称
NUP62 Rabbit Polyclonal Antibody
蛋白名称
Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P37198
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P37198/entry
Mouse Swissprot No.
Q63850
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q63850
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P17955
免疫原
Synthesized peptide derived from human protein . at AA range: 300-380
特异性
NUP62 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008],
组织表达
Brain,Pancreas,Skin,Testis,Urinary bladder,
细胞定位
Nucleus, nuclear pore complex . Cytoplasm, cytoskeleton, spindle pole . Nucleus envelope . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630). .
功能
disease:Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI) [MIM:271930]; also known as infantile bilateral striatal necrosis (IBSN) or infantile bilateral striatal necrosis or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and mental retardation.,domain:Contains F-X-F-G repeats.,function:Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.,PTM:O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, amongst which only one in the C-terminal.,similarity:Belongs to the nucleoporin NSP1/NUP62 family.,subcellular location:Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.,subunit:Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
