产品名称
AP2 alpha (19Z17) Rabbit Monoclonal Antibody
别名
AP 2alpha; AP-2; AP2; AP2TF; BOFS; TFAP2; TFAP2A;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P05549
免疫原
A synthetic peptide of human AP2 alpha
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:50-1:200 FC: 1:20 IP: 1:20-1:50
注意事项
AP2 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
