产品名称
DCR2 (3Q13) Rabbit Monoclonal Antibody
别名
DcR2; TRAIL receptor 4; TRAIL-R4; CD264; TNFRSF10D; DCR2; TRAILR4; TRUNDD;
纯度
Affinity-chromatography
蛋白名称
DCR2, TRAILR4, TRUNDD
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9UBN6
免疫原
A synthetic peptide of human DcR2
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:20
注意事项
DCR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart
细胞定位
Membrane; Single-pass type I membrane protein.
功能
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:
9382840, it cannot but according to PubMed:
9430226, it can induce the NF-kappa-B pathway.
