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PDZK1 (10M11) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM6347
产品名称
PDZK1 (10M11) Rabbit Monoclonal Antibody
别名
CAP70; CLAMP; PDZD1; NHERF3; NHERF-3;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
PDZK1
蛋白名称
CAP70, NHERF3, PDZD1
推荐应用
WB
反应种属
Human
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Gene ID
5174
Human Swissprot No.
Q5T2W1
稀释度
WB 1:500~1:2000 IP 1:50
预测分子量
57kDa
同种型
Rabbit IgG
注意事项
PDZK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
细胞定位
Membrane {ECO:0000250|UniProtKB:Q9JJ40}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes {ECO:0000250|UniProtKB:Q9JJ40}
功能
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
期货
现货

Western blot analysis of PDZK1 expression in T47-D cell lysate.

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