RM6326

Poliovirus Receptor (1D19) Rabbit Monoclonal Antibody

CD155; HVED; mE4; Necl5; PVR; PVS; Taa1; TAGE4;

Affinity-chromatography

常规抗体

PVR

PVS

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

5817

P15151

Recombinant protein of human Poliovirus Receptor/PVR

WB: 1:1000 IHC: 1:50

60-80kDa

45kDa

Rabbit IgG

Poliovirus Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein [Isoform Beta]: Secreted.

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.

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