产品名称
TRIM29 (18R2) Rabbit Monoclonal Antibody
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q14134
免疫原
A synthetic peptide of human TRIM29
注意事项
TRIM29 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in placenta, prostate and thymus.
细胞定位
Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments
功能
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
