RM6322

KAISO (14H11) Rabbit Monoclonal Antibody

Kaiso; Zbtb33; ZNF Kaiso; ZNF348;

Affinity-chromatography

常规抗体

ZBTB33

KAISO, ZNF348

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

10009

Q86T24

A synthetic peptide of human Kaiso

WB: 1:1000-1:5000

90kDa

75kDa

Rabbit IgG

KAISO Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in vascular endothelium.

Nucleus. Cytoplasm Note=Also cytoplasmic in cells grown at high densities

Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).

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