RM6319

WASP (3Z3) Rabbit Monoclonal Antibody

IMD2; SCNX; THC; THC1; U42471; Was; WASp;

Affinity-chromatography

常规抗体

WAS

IMD2

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

7454

P42768

A synthetic peptide of human WASP/Wiskott-Aldrich syndrome protein

WB: 1:2000-1:10000 IHC: 1:100 ICC/IF: 1:100 FC: 1:20

60kDa

53kDa

Rabbit IgG

WASP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.

Cytoplasm, cytoskeleton. Nucleus

Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

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