产品名称
ICOS (16D3) Rabbit Monoclonal Antibody
别名
AILIM; CD278; CRP1; CVID1; ICOS;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9Y6W8
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50
注意事项
ICOS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Activated T-cells. Highly expressed on tonsillar T- cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus
细胞定位
[Isoform 1]: Cell membrane; Single- pass type I membrane protein
功能
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching of immunoglobin isotypes (By similarity).
