RM6312

ATGL / PNPLA2 (16Z14) Rabbit Monoclonal Antibody

ATGL; Desnutrin; plpl; plpl2; Pnpla2; TTS 2.2; TTS2; TTS2.2; ZETA;

Affinity-chromatography

常规抗体

PNPLA2

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

57104

Q96AD5

Recombinant protein of human Adipose Triglyceride Lipase

WB: 1:1000 IHC: 1:500 ICC/IF: 1:100 IP: 1:20

55kDa

55kDa

Rabbit IgG

ATGL / PNPLA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).

Lipid droplet. Cell membrane; Single-pass type II membrane protein

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:15364929, PubMed:16150821). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone (By similarity). Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3- diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity).

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