产品名称
PRKRA (14W3) Rabbit Monoclonal Antibody
别名
RAX; PACT; DYT16; HSD14;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O75569
免疫原
A synthetic peptide of human PACT (phospho KR activating protein)/PRKRA
稀释度
WB: 1:1000 IHC: 1:20-1:50
注意事项
PRKRA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm, perinuclear region. Cytoplasm.
功能
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
