产品名称
NU153 Rabbit Polyclonal Antibody
蛋白名称
Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49790
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49790/entry
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P49791
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
NU153 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
nucleoporin 153(NUP153) Homo sapiens Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],
组织表达
Epithelium,Ovarian carcinoma,Testis,
细胞定位
Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. .
功能
domain:Contains F-X-F-G repeats.,function:Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.,similarity:Contains 4 RanBP2-type zinc fingers.,subcellular location:Located to the terminal ring structure of the nucleoplasmic cage.,subunit:Interacts with SENP2 and XPO5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
