产品名称
NU133 Rabbit Polyclonal Antibody
蛋白名称
Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8WUM0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WUM0/entry
Mouse Swissprot No.
Q8R0G9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R0G9
免疫原
Synthesized peptide derived from human protein . at AA range: 830-910
特异性
NU133 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
nucleoporin 133(NUP133) Homo sapiens The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed in fetal and adult tissues. Expressed in the brain and kidney.
细胞定位
Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). .
功能
function:Involved in poly(A)+ RNA transport.,similarity:Belongs to the nucleoporin Nup133 family.,subcellular location:Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.,subunit:Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
