RM6293

CRYAA (15B3) Rabbit Monoclonal Antibody

Acry 1; CRYA1; CRYAA; HspB4;

Affinity-chromatography

常规抗体

CRYAA

CRYA1, HSPB4

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

102724652;1409

P02489

WB 1:500~1:2000 ICC/IF 1:50~1:200

20kDa

Rabbit IgG

CRYAA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in the eye lens (at protein level).

Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles

Contributes to the transparency and refractive index of the lens (PubMed:18302245). In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:22120592, PubMed:31792453, PubMed:18199971, PubMed:19595763). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373).

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