RM6290

CBX4 (10P4) Rabbit Monoclonal Antibody

CBX4; hPc2; NBP16; PC2;

Affinity-chromatography

常规抗体

CBX4

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

8535

O00257

WB 1:500~1:2000

61kDa

Rabbit IgG

CBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitous.

Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235)

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).

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