产品名称
HLTF (9A13) Rabbit Monoclonal Antibody
别名
HIP116; HIP116A; HLTF 1; Hltf; HLTF1; p113; RNF80; SMARC A3; SMARCA 3; SMARCA3; SNF2L3; ZBU1;
纯度
Affinity-chromatography
蛋白名称
HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q14527
免疫原
A synthetic peptide of human HLTF
稀释度
WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:20
注意事项
HLTF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
细胞定位
Cytoplasm. Nucleus. Nucleus, nucleolus Nucleus, nucleoplasm. Note=Nuclear localization is stimulated by progesterone.
功能
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
