产品名称
Legumain (8S16) Rabbit Monoclonal Antibody
别名
AEP; cysteine 1; Legumain; LGMN; LGMN1; PRSC1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q99538
免疫原
Recombinant protein of human Legumain
注意事项
Legumain Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous. Particularly abundant in kidney, heart and placenta
功能
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
