RM6262

Cyclophilin 40 (18N12) Rabbit Monoclonal Antibody

Cyclophilin40; CyclophilinD; CYP40; CYPD; PPIase; PPIase D; Ppid; Rotamase; Rotamase D;

Affinity-chromatography

常规抗体

PPID

CYP40, CYPD

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

5481

Q08752

WB 1:1000-5000

41kDa

Rabbit IgG

Cyclophilin 40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed.

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co- chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone- receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.

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