产品名称
Scramblase 1 (14B5) Rabbit Monoclonal Antibody
别名
MmTRA1a; MmTRA1b; Nor1; PLSCR 1; Scramblase1; Tra1; Tra1a; Tra1b; Tras1; Tras2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O15162
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
注意事项
Scramblase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
细胞定位
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm Cytoplasm, perinuclear region. Note=Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925)
功能
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:
9218461, PubMed:
8663431, PubMed:
10770950, PubMed:
9572851, PubMed:
9485382, PubMed:
18629440, PubMed:
23590222, PubMed:
24648509, PubMed:
24343571, PubMed:
32110987, PubMed:
23659204, PubMed:
29748552). Mediates calcium- dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:
27206388, PubMed:
17567603). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:
26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:
15308695). Acts as an attachment receptor for HCV (PubMed:
21806988).
