产品名称
TAB3 (10D17) Rabbit Monoclonal Antibody
别名
MAP3K7IP 3; NAP1; NFkB activating protein 1; Tab3; TAK1 binding protein 3;
纯度
Affinity-chromatography
基因名称
TAB3 {ECO:0000303|PubMed:14633987, ECO:0000312|HGNC:HGNC:30681}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q8N5C8
免疫原
A synthetic peptide of human TAB3
稀释度
WB: 1:1000 ICC/IF: 1:20-1:100
注意事项
TAB3 antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Constitutively overexpressed in certain tumor tissues. [Isoform 2]: Minor transcript.
功能
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:
14633987, PubMed:
14766965, PubMed:
15327770, PubMed:
22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:
14633987, PubMed:
14766965, PubMed:
15327770, PubMed:
22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I- kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:
15327770, PubMed:
22158122).
