产品名称
Phospho-ErbB3 (Y1222) (11E17) Rabbit Monoclonal Antibody
别名
ERBB3; HER3; LCCS2; p180 ErbB3; p45 sErbB3; p85 sErbB3;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P21860
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50
注意事项
Phospho-ErbB3 (Y1222) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Epithelial tissues and brain.
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein
功能
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:
20682778). May also be activated by CSPG5 (PubMed:
15358134). Involved in the regulation of myeloid cell differentiation (PubMed:
27416908).
