产品名称
WAPL (7I9) Rabbit Monoclonal Antibody
别名
FOE; WAPAL; WAPL; Wings apart like homolog;
纯度
Affinity-chromatography
蛋白名称
FOE, KIAA0261, WAPAL
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q7Z5K2
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50
注意事项
WAPL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
细胞定位
[Isoform 2]: Nucleus.
功能
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
