产品名称
PSMA2 (9N7) Rabbit Monoclonal Antibody
别名
HC3; PMSA2; Proteasome component C3; PSC2; PSC3; psmA2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P25787
免疫原
A synthetic peptide of human Proteasome 20S alpha 2
稀释度
WB: 1:1000-1:5000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20
注意事项
PSMA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Nucleus. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:P49722}
功能
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
