产品名称
Desmoplakin (9S12) Rabbit Monoclonal Antibody
别名
Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P15924
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50
注意事项
Desmoplakin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin
细胞定位
Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069). Localizes at the intercalated disk in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9Q557, ECO:0000269|PubMed:12802069}
功能
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
