产品名称
NOSIP Rabbit Polyclonal Antibody
蛋白名称
Nitric oxide synthase-interacting protein (eNOS-interacting protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y314
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y314/entry
Mouse Swissprot No.
Q9D6T0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D6T0
免疫原
Synthesized peptide derived from human protein . at AA range: 220-300
特异性
NOSIP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012],
组织表达
Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
细胞定位
Cytoplasm . Nucleus . Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
功能
domain:The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.,function:Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the NOSIP family.,subcellular location:Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.,subunit:Interacts with NOS1 and NOS3.,tissue specificity:Expressed in heart, brain and lung. Present in endothelial cells (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
