产品名称
MRC2/ENDO180 (10A4) Rabbit Monoclonal Antibody
别名
CD280 antigen; MRC2; ENDO180; KIAA0709; UPARAP;
纯度
Affinity-chromatography
蛋白名称
CLEC13E, ENDO180, KIAA0709, UPARAP
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9UBG0
注意事项
MRC2/ENDO180 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
