产品名称
SMC4 (9Q10) Rabbit Monoclonal Antibody
别名
CAPC; hCAP C; hCAP-C; SMC 4; SMC4; SMC4L1; XCAP C homolog;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9NTJ3
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50
注意事项
SMC4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Higher expression in testis, colon, thymus.
细胞定位
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
功能
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
