产品名称
TYRO3 (5G16) Rabbit Monoclonal Antibody
别名
Brt; BYK; DTK; Etk-2; Rek; RSE; SKY; Tif; tyro3;
纯度
Affinity-chromatography
蛋白名称
BYK, DTK, RSE, SKY, TIF
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q06418
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:100~1:500 IP 1:50
注意事项
TYRO3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Abundant in the brain and lower levels in other tissues
细胞定位
Cell membrane; Single-pass type I membrane protein
功能
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
