RM6197

MTH1 (19R5) Rabbit Monoclonal Antibody

MTH1; NUDT 1;

Affinity-chromatography

常规抗体

NUDT1

MTH1 {ECO:0000303|PubMed:7713500}

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

4521

P36639

Recombinant protein of human MTH1

WB: 1:2000 IHC: 1:20 ICC/IF: 1:100 FC: 1:20 IP: 1:20

18kDa

23kDa

Rabbit IgG

MTH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes

[Isoform p18]: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328) A very small amount of the protein is associated with nuclei (PubMed:7782328).

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed:24695225, PubMed:28679043). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420). Has also a significant hydrolase activity toward 2- oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205).

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