产品名称
NETO1 Rabbit Polyclonal Antibody
蛋白名称
Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8TDF5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TDF5/entry
Mouse Swissprot No.
Q8R4I7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4I7
免疫原
Synthesized peptide derived from human protein . at AA range: 20-100
特异性
NETO1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
组织表达
Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.
细胞定位
[Isoform 2]: Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, postsynaptic density membrane . Component of the postsynaptic density (PSD) of excitatory synapses. .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 1]: Secreted .
功能
function:May play a role in the development and/or maintenance of neuronal circuitry.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 2 CUB domains.,tissue specificity:Isoform 1 and isoform 2 are retina-specific whereas isoform 3 is found in retina as well as at lower levels in adult and fetal brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
