产品名称
MBD2 (5H2) Rabbit Monoclonal Antibody
别名
Demethylase; DMTase; Mbd2; MBD2a;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9UBB5
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
MBD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in brain, heart, kidney, stomach, testis and placenta.
细胞定位
Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase
功能
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
