产品名称
NPTX2 Rabbit Polyclonal Antibody
蛋白名称
Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P47972
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P47972/entry
Mouse Swissprot No.
O70340
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70340
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97738
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
NPTX2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009],
组织表达
Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
功能
cofactor:Binds 2 calcium ions per subunit.,function:Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.,similarity:Contains 1 pentaxin domain.,tissue specificity:Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
