产品名称
ENTPD5 (15J14) Rabbit Monoclonal Antibody
别名
CD39L4; Entpd5; mNTPase; NTPDase 5; PCPH; UDPase ENTPD5;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O75356
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50
注意事项
ENTPD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues
细胞定位
Endoplasmic reticulum. Secreted
功能
Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
