RM6139

COPS3 (3I3) Rabbit Monoclonal Antibody

COP9 subunit 3; cops3; CSN3; JAB 1 containing signalosome subunit 3; SGN3; Signalosome subunit 3;

Affinity-chromatography

常规抗体

COPS3

CSN3

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

8533

Q9UNS2

WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

48kDa

Rabbit IgG

COPS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed. Expressed at high level in heart and skeletal muscle.

Cytoplasm. Nucleus

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

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