产品名称
RAIDD (14W2) Rabbit Monoclonal Antibody
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P78560
免疫原
A synthetic peptide of human RAIDD
稀释度
WB: 1:1000-1:2000 ICC/IF: 1:20-1:50 FC: 1:20 IP: 1:20
注意事项
RAIDD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:O88843}. Nucleus {ECO:0000250|UniProtKB:O88843}
功能
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:
9044836, PubMed:
15073321, PubMed:
16652156, PubMed:
17159900, PubMed:
17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:
8985253).
