产品名称
Dlx5 (19R2) Rabbit Monoclonal Antibody
别名
Distal less homeo box 5; Dlx 5; Homeo box protein DLX 5;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P56178
稀释度
WB 1:500~1:2000 IHC 1:100~1:500 ICC/IF 1:100~1:500 IP 1:50
注意事项
Dlx5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
功能
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
