产品名称
HB EGF (13X8) Rabbit Monoclonal Antibody
别名
DTR; DTS; DTSF; HB-EGF; HBEGF; HEGFL;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q99075
免疫原
A synthetic peptide of human HBEGF
稀释度
WB: 1:2000-1:10000 IHC: 1:20-1:100
注意事项
HB EGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
[Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor
功能
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
