产品名称
NLGN3 Rabbit Polyclonal Antibody
蛋白名称
Neuroligin-3 (Gliotactin homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NZ94
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NZ94/entry
Mouse Swissprot No.
Q8BYM5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BYM5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62889
免疫原
Synthesized peptide derived from human protein . at AA range: 610-690
特异性
NLGN3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009],
组织表达
Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse . Detected at both glutamatergic and GABAergic synapses. .
信号通路
Cell adhesion molecules (CAMs);
功能
disease:Defects in NLGN3 may be the cause of susceptibility to X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.,disease:Defects in NLGN3 may be the cause of susceptibility to X-linked autism 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.,function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta (By similarity). Probably interacts through its C-terminus with DLG4/PSD-95 third PDZ domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
