RM6078

RNF40 (1B3) Rabbit Monoclonal Antibody

BRE 1B; BRE1 B; BRE1B; RBP95; Rnf40; STARING;

Affinity-chromatography

常规抗体

RNF40

BRE1B, KIAA0661

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

9810

O75150

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

114kDa

Rabbit IgG

RNF40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine

Nucleus.

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

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