产品名称
ATP2A1/SERCA1 (18W4) Rabbit Monoclonal Antibody
别名
ATP2A; ATP2A1; SERCA1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O14983
稀释度
WB 1:1000~1:5000 IHC 1:50~1:200 IP 1:50
注意事项
ATP2A1/SERCA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Skeletal muscle, fast twitch muscle (type II) fibers.
细胞定位
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}
功能
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:
10914677).
