RM6071

MARK3 (4Z8) Rabbit Monoclonal Antibody

C-TAK1; cTAK1; Emk2; KP78; Mark3; PAR1A;

Affinity-chromatography

常规抗体

MARK3

CTAK1, EMK2

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

4140

P27448

WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:30 FC 1:50

84kDa

Rabbit IgG

MARK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitous.

Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm

Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

现货