RM6068

FYB (3G12) Rabbit Monoclonal Antibody

ADAP; Fyb; FYN binding protein; p120/p130; SLAP130;

Affinity-chromatography

常规抗体

FYB1

FYB, SLAP130

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

2533

O15117

A synthetic peptide of human FYB

WB: 1:1000-1:5000 IHC: 1:50-1:200 ICC/IF: 1:20-1:50 FC: 1:20

130,120kDa

85kDa

Rabbit IgG

FYB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non- lymphoid tissues

Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000250|UniProtKB:O35601}. Note=Colocalizes with TMEM47 at cell- cell contacts in podocytes. {ECO:0000250|UniProtKB:O35601}

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).

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