产品名称
NLGN1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N2Q7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N2Q7/entry
Mouse Swissprot No.
Q99K10
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99K10
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62765
免疫原
Synthesized peptide derived from human protein . at AA range: 410-490
特异性
NLGN1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, postsynaptic density . Cell junction, synapse, synaptic cleft . Cell junction, synapse, synaptic cell membrane . Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. .
信号通路
Cell adhesion molecules (CAMs);
功能
function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subcellular location:Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities.,subunit:Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain. Interacts with AIP1 and PDZRN3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
