产品名称
FDFT1 (18Y13) Rabbit Monoclonal Antibody
别名
DGPT; ERG9; FDFT1; SQS; Squalene synthase; SS;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P37268
免疫原
Recombinant protein of human FDFT1
稀释度
WB: 1:1000 IHC: 1:500 ICC/IF: 1:50 IP: 1:20
注意事项
FDFT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02769}; Multi-pass membrane protein
功能
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
