产品名称
Prostatic Acid Phosphatase (14A5) Rabbit Monoclonal Antibody
别名
5'-NT; 5'-nucleotidase; ACP3; PAP; Prostatic acid phosphatase; TMPase;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P15309
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50
注意事项
Prostatic Acid Phosphatase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues
细胞定位
[Isoform 1]: Secreted
功能
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:
10506173, PubMed:
15280042, PubMed:
20498373, PubMed:
9584846). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:
10506173, PubMed:
15280042).
