产品名称
MCT1 (6S14) Rabbit Monoclonal Antibody
别名
HHF7; MCT 1; MCT; Slc16a1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P53985
免疫原
A synthetic peptide of human Monocarboxylic acid transporter 1
注意事项
MCT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed
细胞定位
Cell membrane; Multi-pass membrane protein
功能
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
