产品名称
MBD3 (17Y8) Rabbit Monoclonal Antibody
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O95983
免疫原
A synthetic peptide of human MBD3
稀释度
WB: 1:1000 ICC/IF: 1:100 FC: 1:20 IP: 1:20
注意事项
MBD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes
功能
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:
12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:
24307175). Recruits histone deacetylases and DNA methyltransferases.
