产品名称
eEF1A1 (19R16) Rabbit Monoclonal Antibody
别名
EEF1A1; CCS-3; CCS3; EEF-1; EEF1A; EF-Tu; EF1A; GRAF-1EF; LENG7; PTI1;eEF1A-1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P68104
免疫原
A synthetic peptide of human eEF1A1
稀释度
WB: 1:5000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20 IP: 1:20
注意事项
eEF1A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle
细胞定位
Cytoplasm. Nucleus. Nucleus, nucleolus. Cell membrane. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (PubMed:19158340). Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (PubMed:8650580). Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B (PubMed:26497934).
功能
This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:
17177976).
