RM5998

PEN2 (1M2) Rabbit Monoclonal Antibody

PEN 2; PSEN2; psenen;

Affinity-chromatography

常规抗体

PSENEN

PEN2

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

55851

Q9NZ42

A synthetic peptide of human PEN2

WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20-1:100

12kDa

12kDa

Rabbit IgG

PEN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein Note=Predominantly located in the endoplasmic reticulum and in the cis- Golgi.

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

现货