RM5994

PTBP1 (3J11) Rabbit Monoclonal Antibody

PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I;

Affinity-chromatography

常规抗体

PTBP1

PTB

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

5725

P26599

A synthetic peptide of human PTBP1

WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:50 FC: 1:200

57kDa

57kDa

Rabbit IgG

PTBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus.

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).

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